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KMID : 0360320010330040309
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Journal of Korean Cancer Research Association
2001 Volume.33 No. 4 p.309 ~ p.317
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Genetic Alterations in Gastric Carcinomas and Adjacent Mucosa Detected by Comparative genomic Hybridization ( CGH )
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Kim Dong-Wan
Choi Seok-Jin
Lee Jee-Young
Kim Kyu-Jong
Park Moo-In
Park Seun-Ja
Koo Sun-Hoe
Koo Ja-Young
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Abstract
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Purpose: Comparative genomic hybridization (CGH) was used to detectany amplified ordeleted chromosomal
regions in tumors by mapping their locations on normal metaphase chromosomes.
Materials and Methods: Twenty-six gastric carcinomas and their adjacent mucosa were screened for chro-mosomal aberrations using CGH.
Results: All carcinomas had chromosomal aberrations, and chromosomal material was more likely to be gained
than lost. Ten out of 26 adjacent mucosa had chromoso mal aberrations, and again was less frequently observed than a tumor (1.6/2.6). The most common gains were detected on 13q (58.3%), 8q (30.8%), 6q (27.0%), and 20p (19.2%), while the most freque nt losses were de-tected on 17p (38.5%) and 16q (7.2%). The most common chromosomal aberrations in the adjacent mucos a were a gain of 13q (11.5%) and a loss of 17q (11.5%). The tumors had more chromosomalgains of 2q, 3q, and 13q and more losses of 17p and 16q than the adjacent mucosa.
Conclusion: The most common gain in the tumors was detected on 13q, 8q, 6q, and 20p, and the most frequent loss was on 17p and 16q. While CGH may be useful in predicting the prognos is ortherapeutic decision of gastric carcinomas, furthers tudy of several candidate genes, such as DP1, FLT1, c-myb, AIB1, BTAK, is needed to clarify gastric carcinogenes is and its progression.
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KEYWORD
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Stomach neoplasm, Gene alterations, Comparative genomic hybridization,
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